Peer-review in a world with rational scientists: Toward selection of the average

One of the virtues of peer review is that it provides a self-regulating selection mechanism for scientific work, papers and projects. Peer review as a selection mechanism is hard to evaluate in terms of its efficiency. Serious efforts to understand its strengths and weaknesses have not yet lead to clear answers. In theory peer review works if the involved parties (editors and referees) conform to a set of requirements, such as love for high quality science, objectiveness, and absence of biases, nepotism, friend and clique networks, selfishness, etc. If these requirements are violated, what is the effect on the selection of high quality work? We study this question with a simple agent based model. In particular we are interested in the effects of rational referees, who might not have any incentive to see high quality work other than their own published or promoted. We find that a small fraction of incorrect (selfish or rational) referees can drastically reduce the quality of the published (accepted) scientific standard. We quantify the fraction for which peer review will no longer select better than pure chance. Decline of quality of accepted scientific work is shown as a function of the fraction of rational and unqualified referees. We show how a simple quality-increasing policy of e.g. a journal can lead to a loss in overall scientific quality, and how mutual support-networks of authors and referees deteriorate the system.Comment: 5 pages 4 figure

Plasma Cholesterol Ester Fatty Acids: A New Biochemical Abnormality in Obstructive Jaundice

Changes in fatty acid patterns may explain many of the observed abnormalities found in obstructive jaundice. This study looked at fatty acids in plasma cholesterol esters, in a group of patients with obstructive jaundice and a matched group of controls. Significant abnormalities were demonstrated, most importantly a fall in essential fatty acids, in the jaundiced group. Overall the saturation of this fraction, as assessed by double bond index, rose. The essential fatty acids are important as factors in membrane function and as precursors of eicosanoids. The abnormalities found in this study provide further evidence of the significance of EFA in patients with obstructive jaundice

Treatment of premenstrual tension with lithium carbonate – A PILOT STUDY

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/66408/1/j.1600-0447.1980.tb00569.x.pd

The effects of n-6 polyunsaturated fatty acids on the expression of nm-23 in human cancer cells.

This study examined the effect of n-6 polyunsaturated fatty acids (PUFAs) on the expression of nm-23, a metastasis-suppressor gene, in two highly invasive human cancer cell lines, HT115 and MDA MB 231. A range of n-6 and n-3 PUFAs were tested. We report that while linoleic acid and arachidonic acid reduced the expression of nm-23-H1, gamma linolenic acid (GLA) and its soluble lithium salt markedly increased the expression of the molecules. The stimulation of the expression of nm-23 by GLA was seen at both protein and mRNA levels. Up-regulation of nm-23 was also associated with a reduction of the in vitro invasiveness of these cells. It is concluded that gamma linolenic acid (GLA) enhances the expression of nm-23. This contributes to the inhibition of the in vitro invasion of tumour cells

Inhibition of hepatocyte growth factor-induced motility and in vitro invasion of human colon cancer cells by gamma-linolenic acid.

In this study we have determined the effects of the n-6 essential fatty acid gamma-linolenic acid (GLA) on the motility and invasive/metastatic nature of the human colon cancer cell lines HT115, HT29 and HRT18. Cell motility was induced by hepatocyte growth factor/scatter factor (HGF/SF) and measured by both colony scattering and dissociation from carrier beads. Invasiveness was measured in vitro by cellular invasion into extracellular matrix. At concentrations up to 100 microM (which had no effect on cell growth over the duration of the experiments) both cell motility and invasion induced by HGF/SF were markedly reduced by GLA and its lithium salt. The attachment of these cells to the extracellular matrix components (Matrigel and fibronectin) was also inhibited. There were also changes in the cell-surface E-cadherin, but not fibronectin receptor at similar concentrations. It is concluded that n-6 essential fatty acids have the ability to inhibit both motility and invasiveness of human colon cancer cells, perhaps by modifying cell-surface adhesion molecules

Nuclear Activity and the Conditions of Star-formation at the Galactic Center

The Galactic Center is the closest galactic nucleus that can be studied with unprecedented angular resolution and sensitivity. We summarize recent basic observational results on Sagittarius A* and the conditions for star formation in the central stellar cluster. We cover results from the radio, infrared, and X-ray domain and include results from simulation as well. From (sub-)mm and near-infrared variability and near-infrared polarization data we find that the SgrA* system (supermassive black hole spin, a potential temporary accretion disk and/or outflow) is well ordered in its geometrical orientation and in its emission process that we assume to reflect the accretion process onto the supermassive black hole (SMBH).Comment: 11 pages, 4 figures, 1 table; published in PoS-SISSA Proceedings of the: Frontier Research in Astrophysics - II, 23-28 May 2016, Mondello (Palermo), Ital

How to Create an Innovation Accelerator

Too many policy failures are fundamentally failures of knowledge. This has become particularly apparent during the recent financial and economic crisis, which is questioning the validity of mainstream scholarly paradigms. We propose to pursue a multi-disciplinary approach and to establish new institutional settings which remove or reduce obstacles impeding efficient knowledge creation. We provided suggestions on (i) how to modernize and improve the academic publication system, and (ii) how to support scientific coordination, communication, and co-creation in large-scale multi-disciplinary projects. Both constitute important elements of what we envision to be a novel ICT infrastructure called "Innovation Accelerator" or "Knowledge Accelerator".Comment: 32 pages, Visioneer White Paper, see http://www.visioneer.ethz.c

Experimental Indicators of Accretion Processes in Active Galactic Nuclei

Bright Active Galactic Nuclei are powered by accretion of mass onto the super massive black holes at the centers of the host galaxies. For fainter objects star formation may significantly contribute to the luminosity. We summarize experimental indicators of the accretion processes in Active Galactic Nuclei (AGN), i.e., observable activity indicators that allow us to conclude on the nature of accretion. The Galactic Center is the closest galactic nucleus that can be studied with unprecedented angular resolution and sensitivity. Therefore, here we also include the presentation of recent observational results on Sagittarius A* and the conditions for star formation in the central stellar cluster. We cover results across the electromagnetic spectrum and find that the Sagittarius A* (SgrA*) system is well ordered with respect to its geometrical orientation and its emission processes of which we assume to reflect the accretion process onto the super massive black hole.Comment: 16 pages, 4 figures, conference proceeding: Accretion Processes in Cosmic Sources - APCS2016 - 5-10 September 2016, Saint Petersburg, Russi